LB492 S15
Senior Seminar: Evolutionary Medicine
Core Reading List
(updated Apr. 6, 2015)

Course Texts

The two course texts, Why We Get Sick, and Evolutionary Medicine, will be used extensively throughout the semester and serve as good reference texts as well. The notes and bibliographies in both books are excellent.

1. Nesse RM, Williams GC (1996) Why We Get Sick: The New Science of Darwinian Medicine, Vintage Press, NY.

2. Gluckman P, Beedle A, Hanson M. 2009. Principles of Evolutionary Medicine, Oxford University Press, NY.

Core Readings for Class
(Core Readings Available at the Course D2L Website)

The Core Readings will form the basis for discussion in class. At a minimum, students should read the Core Readings, but other readings will also be made available. Student presenters/discussion leaders and, hopefully, other students will go beyond the Core Readings to constuct their own understanding of the topics to be discussed. This is the true spirit of a "seminar".

Read for Mon. 1/12/15 "Engagement"

  1. Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL (2013) Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol 11(5): e1001571. doi: 10.1371/journal.pbio.1001571

Read for Wed. 1/14/15 "Homology: Deep and Otherwise"

  1. Zimmer C (2010) The Search for Genes Leads to Unexpected Places New York Times (online) 26 April 2010.
  2. McGary KL et al. (2010) Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc. Natl. Acad. Sci. USA 107: 6544-6549.

Read for Wed. 1/21/15 "Introducing the Genetics of Human Populations"

  1. Tishkoff S, Williams SM (2002) Genetic analysis of African Populations: Human evolution and complex disease. Nature Reviews Genetics 3: 611-621.

Read for Mon. 1/26/15 "Genes and Disease"

  1. Nesse RM, Williams GC (1994) Genes and Disease: Defects, Quirks, and Compromise. Ch. 7 in: Why We Get Sick: The New Science of Darwinian Medicine, Vintage Press, NY.

Read for Wed. 1/28/15 "Legal Culpability and Genetic Predisposition" (Dr. Sean Valles, guest lecture)

  1. Tabery J (2009) From a Genetic Predisposition to an Interactive Predisposition: Rethinking the Ethical Implications of Screening for Gene-Environment Interactions. Journal of Medicine and Philosophy, 34: 27-48.
  2. Aspinwall LG, Brown TR, Tabery J (2012) The Double-Edged Sword: Does Biomechanism Increase or Decrease Judges' Sentencing of Psychopahts? Science 337: 846-849.

Read for Mon. 2/2/15 "The Adaptationist Programme"

  1. Gould SJ, Lewontin RC (1979) The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the AdaptationistProgramme, Proceedings of the Royal Society of London. Series B, 205: 581-598.

Read for Wed. 2/4/15 "Non-adaptive Explanations of Phenotypic Evolution"

  1. Finn CA (1998) Menstruation: A Nonadaptive Consequence of Uterine Evolution. The Quarterly Review of Biology 73: 163-173.
  2. Profet M (1993) Menstruation as a Defense Against Pathogens Transported by Sperm. The Quarterly Review of Biology 68: 335-386. (Abstract Only)
  3. Strassmann BI (1996) The Evolution of Endometrial Cycles and Menstruation. The Quarterly Review of Biology 71: 181-220.(Abstract Only)

Read for Mon. 2/9/15 "From Altruism to Genetic Imprinting: A Framework for Studying Parent Offspring Conflict"

  1. Nesse and Williams, pp. 197-200 (Pregnancy).
  2. Gluckman et al., pp. 88-91 (Sec. 4.6, Epigenetic mechanisms) and pp. 172-173 (Sec. 7.9.8, Conflict in Development)
  3. Freeman and Herron, pp. 420-422 (Inclusive Fitness)
  4. Costancia M, Kelsey G, Reik W (2005) Resourceful Imprinting. Nature 432:53-57. (Suppl.)
  5. Badcock C, Crespi B (2008) Battle of the sexes may set the brain. Nature 454: 1054-1055. (Suppl.)

Read for Wed. 2/11/15 "Parent Offspring Conflict - The Theoretical Basis"

  1. Haig DL (2010) Transfers and transitions: Parent-offspring conflict, genomic imprinting, and the evolution of human life history. PNAS 107: 1731-1735.
  2. Trivers RL (1974) Parent-Offspring Conflict. American Zoologist 14: 249-264. (Suppl.)

Read for Mon. 2/16/15"Molecular Evolutionary Processes in Humans"

  1. Johnson NA, Smith JJ, Pobiner B, Schrein C 2012) Why are chimps still chimps? American Biology Teacher 74: 74-80.
  2. Zimmer C (2011) The Brain: A body fitt for a freaky big brain. Discover Jul-Aug (online)
  3. Fedrigo O, Pfefferle AD, Babbitt CC, Haygood R, Wall CE, Wray GA (2011) A potential role forglucose transporters in the evolution of human brain size. Brain, Behavior and Evolution 78: 315-326. (suppl.)
  4. Tishkoff SA, et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe. Nature Genetics 39: 31-40. (suppl.)

Read for Wed. 2/18/15"Evolution and Natural History of Skin"

  1. Gibbons A (2014) Shedding light on skin color. Science 346: 934 - 936.
  2. Jablonski NG (2006) Skin: A Natural History, chapters 4 & 6, University of California Press, Berkeley, CA.
  3. Watt FM (2014) Mammalian skin cell biology: At the interface between laboratory and clinic. Science 346: 937 - 940. (suppl.)

Read for Mon. 2/23/15 "Arms Races I"

  1. NOVA (2001) Evolution: A Journey into Where We're From and Where We're Going. Program 4: The Evolutionary Arms Race. WGBH, Boston.

Read for Wed. 2/25/15 "Arms Races II"

  1. Nesse RM, Williams GC (1994) An Arms Race Without End. Ch. 4 in: Why We Get Sick: The New Science of Darwinian Medicine, Vintage Press, NY.

Read for Mon. 3/2/15 "Arms Races III"

  1. Labrie SJ, Samson JE, Moineau S (2010) Bacteriophage resistance mechanisms. Nature Reviews Microbiology 8: 317 - 327.
  2. Kutateladze M, Adamia R (2010) Bacteriophages as potential new therapeutics to replace of supplement antibiotics. Trends in Biotechnology 28: 591 - 595.
  3. Lu TK, Koeris MS (2011) The next generation of bacteriophage therapy. Current Opinion in Microbiology 14: 524-531.
  4. Dawkins R, Krebs JR (1979) Arms races between and within species. Proc. R. Soc. Lond. B 205: 489-511. (suppl.)

Read for Mon. 3/16/15 "Evolution of Pain I"

  1. Nesse and Williams, pp. 35-36 and pp. 67-68 (Pain and Malaise; Avoidance of Injury).
  2. Treede et al. (1999) The cortical representation of pain. Pain 79: 105-111. (Supplementary Reading)
  3. Acerbi & Parisi (2007) Evolution of Pain. in F. Almeida e Costa et al. (Eds.): ECAL, LNAI 4648, pp. 816-824. (Supplementary Reading)

Read for Wed. 3/18/15 "Evolution of Pain II"

  1. Lumpkin & Caterina (2007) Mechanisms of sensory transduction in the skin. Nature 445: 858-865.
  2. St. John Smith & Lewin (2009) Nociceptors: a phylogenetic view. J. Comp. Physiol. A 195: 1089-1106.
  3. Liebeskind BJ, Hillis DM, Zakon HH. 2015. Convergence of ion channel genome content in early animal evolution. Proc. Natl. Acad. Sci. USA (doi: 10.1073/pnas.1501195112)

Read for Mon. 3/23/15 "Dreams and Sleep"

  1. Nesse and Williams, pp. 226-230 (Sleep Disorders; Dreaming)
  2. Gluckman et al., p. 230 (Sec. 9.6; Sleep and Repair)

Read for Wed. 3/25/15 "Dreams and Sleep"

  1. Siegel JM (2009) Sleep viewed as a state of adaptive inactivity. Nature Reviews Neuroscience 10: 747-753.
  2. Siegel JM (2005) Clue to the functions of mammalian sleep. Nature 437:1264-1271.

Read for Mon. 3/30/15 "Mental Health"

  1. Nesse and Williams, Ch. 14 (Are Mental Disorders Diseases?)

Read for Wed. 4/1/15 "Mental Health"

  1. Crespi B, Stead P, Elliot M (2010) Comparative genomics of autism and schizophrenia.  PNAS 107 S1: 1736-1741.

Read for Mon. 4/6/15 "Addiction and Substance Abuse"

  1. Nesse and Williams, pp. 102-106; pp. 151-152 (Genetic quirks; Don't let genes scare you; Addictions)
  2. Durrant R, Adamson S, Todd F, Sellman D (2009) Drug use and addiction: evolutionary perspective. Australian and New Zealand Journal of Psychiatry 43: 1049 - 1056.

Read for Wed. 4/8/15 "Addiction and Substance Abuse"

  1. Stephens D, Dudley R (2004) The drunken monkey hypothesis. Natural History Dec. 2004/Jan. 2005 40-44.
  2. Dudley R (2002) Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover? Addiction 97: 381-388.

Read for Mon. 4/13/15 "The E. coli Long Term Evolution Experiment (LTEE)"

  1. Lenski RE, Travisano M (1994) Dynamics of Adaptation and Diversification: A 10,000-generation Experiment with Bacterial Populations. Proc. Natl. Acad. Sci. USA 91: 6808-6814.
  2. Woods R, Schneider D, Winkworth CL, Riley MA, Lenski RE (2006) Tests of parallel molecular evolution in a long-term experiment with Escherichia coli. Proc. Natl. Acad. Sci. USA 103: 9107-9112.

Read for Wed. 4/15/15 "Parallel Evolution Identifies Pathogenicity Genes"

  1. Lenski RE (2011) Chance and necessity in the evolution of a bacterial pathogen. Nature Genetics 43: 1174-1176.
  2. Lieberman TD, Michel J-B, Aingaran M, Potter-Bynoe G, Roux D, Davis Jr. MR, Skurnik D, Leiby N, LiPuma JJ, Goldberg JB, McAdam AJ, Priebe GP, Kishony R (2011) Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nature Genetics 43: 1275-1280.

Read for Wed. 4/22/15 "TBD"

  1. TBD.


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Last Updated Apr. 6, 2015 (JS)