LBS 333
Fall 2000
Topics in the History of Genetics and Molecular Biology

                                    Instructor: Craig Stillwell
                                    Lyman Briggs School
                                    Office: E-185 Holmes Hall
                                    Phone: 432-2268
                                    Email: stillwe1@pilot.msu.edu
                                                  Office Hours:  Mondays, 1:30-2:30  (tentative)
                                                                        Wednesdays, 2:00-3:00 (tentative)
                                                                                         (and by appointment)

    This site last updated on   28 November 2000.

                                                                    If you have comments or suggestions, email me at stillwe1@pilot.msu.edu

Fall 2000 Syllabus

Instructor Course Description  Course ObjectivesTextsCourse Requirements  Evaluation

New Grading Scheme!

            Reading and Assignments Schedule

Week 1  Week 2     Week 3  Week 4  Week 5   Week 6   Week 7    Week 8   Week 9

Week 10   Week 11    Week 12  Week 13  Week 14  Week 15    Week 16


Fifth Essay Writing Assignment(Due Friday, Dec. 15) 

Fourth Essay Writing Assignment(Due Friday, Dec. 1)

More Extra Credit Opportunities:

1) Attend Anne McLaren's lecture on cloning (Wed. Nov. 29): 50 bonus points

                Click Here for more information.

                Click Here for an Anne McLaren essay on cloning.

2) Attend the showing of GATTACA on Tuesday, Dec. 5, 5:30-7:30
        and participate in a class discussion about the film on Thursday, Dec. 7: 100 bonus points.

Extra Credit Opportunity:

                                Ruth Hubbard, "The Double Helix: A Study of Science in Context"

The Writing Desk

 Essay Format Handout  Standards of Evaluation  Revising & Rewriting Handout

                     Composing Essays: Some Helpful Suggestions (and Pet Peeves of Mine)

The Writing Center  Plagiarism Handout    Writing Purposes

 General Comments about Common Errors made on the Diagnostic Essay


The Study Den


J. Craig Venter Page    

Pulitzer Prize-winning Harvard entomologist (and world's leading expert on ants),
E. O. Wilson, describes James Watson at Harvard in the late-fifties and sixties:

                The Molecular Wars 


Tom Maniatis


Biography of Andre Lwoff (1902-1994)

Biography of Jacques Monod (1910-1976)            Ode to Monod


Biography of François Jacob (1920-- )

QuickTime Interview of François Jacob

           From left to right: Francois Jacob (1920- ), Jacques
           Monod (1910-1976) and André Lwoff (1902-1994).
           Awarded the Nobel Prize for Physiology or Medicine in1965.
           Jacques Monod was director of the Pasteur
           Institute in Paris from 1971 to 1976.

Bacterial Sex!


High Points in the History of Bacterial Sex!

1945--Conjugation discovered in E. coli K12 by Joshua Lederberg and Edward Tatum.

1952--Existence of sexual differentiation (male and female bacteria!) discovered by William Hayes
            (and independently by Joshua and Esther Lederberg with Luca Cavilli-Sforza).

1953--High-Frequency (Hfr) strains of E. coli K12 discovered by William Hayes.

1955--Waring Blender coitus interruptus experiments of François Jacob and Elie Wollman lead
        to the "spaghetti hypothesis" and ability to map the genes of E coli measured in units of time.

1956--Thomas Anderson takes an electron micrograph of bacteria caught in the act of conjugation.

1957--Arthur Pardee, Jacob, and Monod design and carry out the PAJAMO experiment that
            mates Hfr wild type males (inducible and with gene for beta-galactosidase) with constitutive
            (non-inducible) females that lacked the beta-galactosidase gene. The correct interpretation of
            the results of this experiment, made a little over two years later (April 15 (Good Friday) 1960),
            led to the postulation of messenger RNA.

A Brief History of the Institut Pasteur (by François Jacob)

Francis Crick Page

Seymour Benzer Page

Rosalind Franklin Page

 James Watson's Excellent European Adventure James Watson Page

Horace Freeland Judson Website

Web Page Archives

The next lecture in the SCIENCE CHANGING SOCIETY series associated with the
McPherson Professorship will be held this week:

Anne McLaren, "Cloning: Pathways to a Pluripotent Future"

November 29th, 7:30 PM,

Fairchild Theater at the MSU Auditorium,

Anne McLaren is Principal Research Associate at the Wellcome/CRC Institute
of Cancer Research and Developmental Biology at Cambridge University.  Her
research has concentrated on the genetics, reproductive biology, and
developmental biology of mammals, using the laboratory mouse as a model.
Prior to joining the Institute, she was Director of the Medical Research
Council's Mammalian Development Unit and worked for the UK Agricultural
Research Council.  She is a member of both the European Group on Ethics,
which advises the European Commission on social and ethical implications of
new technologies, and the Human Fertilisation and Embryology Authority in
the UK, which regulates in vitro fertilization and human embryo research.
Among her many awards, she is a Fellow of the Royal Society, received the
Society's Royal Medal in 1990, and served as its Vice-President, the first
woman Officer in 332 years).  Anne McLaren was made a Dame of the British
Empire in 1993.  In addition to numerous publications, she is also the
author of the June, 2000 article on "Cloning: Pathways to a Pluripotent
Future" in the Pathways of Discovery Essay Series in the journal Science.