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Michigan State UniversityBreedlove Jordan lab at MSU

Chieh Chen

Chieh Chen

I am a graduate student pursuing a PhD in Behavioral Neuroscience. I am interested in understanding the role of sex hormones in mental disorders. Presently, my research seeks to understand the role of androgens and androgen receptors (AR) in anxiety-related behavior. For this, I am using the Cre-LoxP system for conditional androgen receptor knockout in the mouse model, referred to as "iTfm" (induced testicular feminization mutation) in our lab. The iTfm model is created by crossing animals carrying a floxed allele of exon 2 of the AR with mice carrying a gene for CRE recombinase enzyme, resulting in dysfunctional AR. These mice are tested for anxiety-related behavior in different paradigms, and their brains are later studied for anatomical and molecular measurements. This mouse model allows for temporal and tissue specific knockout of the androgen receptor. Therefore, this project's future path will be determined by the outcome of the present study.