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Michigan State UniversityBreedlove Jordan lab at MSU

Cindy Jordan

Cindy Jordan

I have a long-standing interest in the cellular and molecular mechanims underlying steroid-regulated behaviors. My early studies focused on the androgenic stabilization and maintenance of synapses, with a later interest in the potential role of glia in this process. I have also developed an interest in the molecular pathways by which androgens directly influence cells, including the potential contribution of steroid receptor coregulators in cellular responses to androgens. Most recently, studies have led me into the world of neurodegenerative diseases, having inadvertently developed a new model for Spinal Bulbar Muscular Atrophy (SBMA) or Kennedy's Disease, an androgen-dependent motoneuron disease (more information about this topic on our main web page). Most studies to date in my lab are based on a sexually dimorphic neuromuscular rodent model system (the SNB system) whose function and morphology are profoundly sensitive to gonadal androgens. The SNB system is the behavioral unit controlling penile reflexes. Such reflexes are active during male copulatory behavior, an androgen-dependent behavior. Thus, this relatively simple model system is especially well suited for identifying and understanding the cellular and molecular mechanisms mediating steroid-regulated behavior. Approaches used in my lab include various behavioral assays, immunocytochemistry, tract tracing, Western, Northern and Southern blotting, reverse transcriptase-polymerase chain reaction (end point and real time), in situ hybridization, gene cloning, transfection and transgenesis. We also maintain mutant rat and mouse colonies that have the testicular feminization mutation (tfm). This mutation is in the androgen receptor gene and renders males insensitive to their own androgens. These androgen-insensitive rodents are powerful tools, among others, that we use in our studies.

Media

  • Michigan State University News Release: "Too much of a good thing: When testosterone is bad for muscles"
    Thursday, November 1, 2007
  • Monks, D. A., Johansen, J. A., Mo, K., Rao, P., Eagleson, B., Yu, Z., Lieberman, A. P., Breedlove, S. M., & Jordan, C. L. (2007). Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proceedings of the National Academy of Sciences, 104(46), 18259-18264. | PDF | Video Supplement

More on Cindy

Contact Cindy

  • Phone: (517) 355-1722
  • Fax: (517) 432-2744
  • Email: jordancy [at] msu [dot] edu

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