My Research Interests

My research interest covers the following areas.
1). Statistical shrinkage models and variable selection via the Lasso.
Tibshirani's Lasso page and my shooting algorithm.
2). Longitudinal studies,
3). Regressions with singular designs and age-period-cohort (APC) models,
4). Statistical computing and small sample problems,
5). Microarray gene expression data analysis and genetic association studies (SNP data analysis), haplotype analysis and
6). Estimating DNA copy numbers and SNP genotype calling.

Age-Period-Cohort Analysis - One of the Controversies in the 20th Century

Statistical sofware I invented .
APCSoft - A statistical software for APC analysis for epidemiologists, sociologists and demographers.
It's available on the internet FREE of charge!!
(Sponsor: MSU IRGP - Vice President for Research).
(AVAILABLE NOW. Please visit and provide comments.)

Award and Grants

ASA Computing Committee, 1997, Student paper Competition Award.

National Cancer Institute, 1999 - 2002. Statistical age-period-cohort analysis of cancer incidence and mortality rates.

Michigan State University, 2000-2003. A web-based software for statistical APC analysis of disease rates.

National Cancer Institute / NIH, 2003-2005. Research fellowship (PI: Ray Carroll at TAMU)

NICHD/NIH, Feb, 2006 - Sept, 2007. Statistical genetic association study of pregnancy complications.

Selected Publications In Major Research Areas

Statistical variable selection and Lasso

Fu, WJ. Penalized regressions: the Bridge versus the Lasso, J. Computational and Graphical Statistics, 1998; 7,3: 397-416.

Knight, K. and Fu, WJ. Asymptotics for Lasso-type estimators, Annals of Statistics, 2000;28:1356-1378.

Fu, WJ. Penalized estimating equations, Biometrics, 2003;59:126-132.

Fu, WJ. Nonlinear GCV and quasi-GCV for shrinkage models. J. Stat. Plan. Infer. 2005.

Age-Period-Cohort Analysis

Yang Y. Fu, WJ. and Land K., A methodological comparison for age-period-cohort models:
the intrinsic estimator method versus conventional generalized linear models, Socialogical Methodology, 2004.

Fabio, A. Lober, R. Balasubramani,G.K. Roth, J. Fu, WJ. and Farrington, DP.
“Why Some Generations Are More Violent Than Others: Assessment of Age, Period and Cohort Effects.” American Journal of Epidemiology. 164:151-160, 2006.

Fu, WJ and Hall, P. 2006,
Asymptotic Properties of Estimators in Age-Period-Cohort Analysis. Statistics and Probability Letters. 76, 1925-1929.

Fu, WJ. A Smoothing Cohort Model in Age-period-cohort Analysis with Applications to Homicide Arrest Rates and Lung Cancer Mortality Rates.
Sociological Methods and Research, 2007.

Yang, Y. Schulhofer-Wohl, S. Fu, WJ and Land, K. The intrinsic estimator for age-period-cohort analysis: what it is and how to use it. Amer. J. Sociol. 113, 6:1697-1736, 2008.

Bioinformatics and Computational Genomics

Fu, WJ. Dougherty, E.R. Mallick, B. and Carroll, R. How many samples are needed to train a classifier
- a sequential approach. Bioinformatics, 2005.

Fu, WJ. Wang, S. and Carroll, R. Estimating misclassification errors with small samples via bootstrap cross-validation. Bioinformatics, 2005.

Fu, WJ. Hu, J. Spencer, T. Carroll, R. Wu, G. Statistical Models in assessing fold-change of gene expressions in real-time RT-PCR experiments.
Computational Biology and Chemistry, 2006.

Cui, Y. Fu, WJ. Sun, K. Romero, R. Wu, R. Mapping Nucleotide Sequences That Encode Complex Binary Disease Traits with HapMap.
Current Genomics 8(5): 307-322, 2007.

Cui, Y. Kang, GL. Sun, R. Romero, R. Qian, M. and Fu, WJ. Gene-centric genomewide association study via entropy. Genetics.
179: 637-650. 2008.

Duan, S. Wan, L. Fu, WJ. Pan, H. Ding, Q. Chen, C. Han, P. Zhu, X. Du, L. Liu, R. Chen, Y. Xie, R. Yan, X. Deng, M. Qian, M.
Nonlinear cooperation between p53 and ING1 induces bax in mouse thymocyte apoptosis: A quantitative approach. Apoptosis, December, 2008. DOI 10.1007/s10495-008-0288-4

Fu, WJ. Li, M. Wan, L. Deng, M. Qian, M. On design of oligonucleotide SNP array and methods for genotype calling,
IEEE Computer Science, Proceedings of the 2008 International Conference BMEI 2008, 453-458, 2008.

Fu, WJ. Mallick, B. and Carroll, R. Why do we observe classification errors smaller than Bayes error?
J. Statist. Comp. Simul., November, 2008. DOI: 10.1080/00949650801905221

Wan, L. Fu, WJ. Deng, M. Qian, M. A method of correcting systematic bias in Affymetrix SNP array.
IEEE Computer Science, Proceedings of the 2008 International Conference of BMEI, 442-446, 2008.

Molina-Molina, M. Xaubet, A. Li, X. Abdul-Hafez, A. Friderici, K. Jernigan, K. Fu, WJ. Ding, Q. et al.
Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression, Eur. Respiratory J. 32:1004-1008, 2008.

Wan, L. Li, D. Zhang, D. Liu, X. Fu, WJ. Zhu, L. Deng, M. Sun, F. and Qian, M. Conservation and implications
of eukaryote transcriptional regulatory regions across multiple species, BMC Genomics, December, 2008. DOI 10.1186/1471-2164-9-623

Jobgen, W. Fu, WJ Gao, H Li, P. Meininger, CJ. Smith, SB. Spencer, TE. Wu, G.
High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acid, 37:187-198, 2009. DOI: 10.1007/s00726-009-0246-7.

Wan, L. Sun, K. Ding, Q. Cui, Y. Li, M. Wen, Y. Elston, RC. Qian, M. Fu, WJ. Cross-hybridization modeling on oligonucleotide SNP arrays
for accurate DNA copy number estimation. Nucleic Acids Res. 2009, doi:10.1093/nar/gkp559

Fu, WJ. Li, M. Wen, Y. Preeyanon, L. Some critical data quality control issues in oligoarrays, in Frontiers in Computational and Systems Biology, ed. Feng, Fu and Sun. Springer, 2009.