Therapeutic Microbiology Laboratory


Recent Journal Articles

Gulati M., Jain N., Anand B., Prakash B., Britton R.A. Mutational analysis of the ribosome assembly GTPase RbgA provides insight into ribosome interaction and ribosome-stimulated GTPase activation. (2013) Nucleic Acids Res. 41(5):3217-27

McCabe L.R., Irwin R., Schaefer L., Britton R.A. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. (2013) J.Cell Physiol. 228:1793-8.

van Pijkeren J.P., Neoh K.M., Sirias D., Findley A.S., Britton R.A. Exploring optimization parameters to increase ssDNA recombineering in Lactococcus lactis and Lactobacillus reuteri. (2012) Bioengineered. 3:209-17.

De Weirdt R., Crabbe A., Roos S., Vollenweider S., Lacroix C., van Pijkeren J.P., Britton R.A., Sarker S., Van de Wiele T., Nickerson C.A. Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium. (2012) PLoS One. 7(5):e37116. Epub 2012 May 31.

Thomas C.M., Hong T., van Pijkeren J.P., Hemarajata P., Trinh D.V., Hu W., Britton R.A., Kalkum M., Versalovic J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. (2012) PLoS One. 7(2):e31951. Epub 2012 Feb 22.

van Pijkeren J.P., Britton R.A. High efficiency recombineering in lactic acid bacteria. (2012) Nucleic Acids Res. 40(10):e76. Epub 2012 Feb 10.

Achila D., Gulati M., Jain N., Britton R.A. Biochemical characterization of ribosome assembly GTPase RbgA in Bacillus subtilis. (2012) J Biol Chem. 287(11):8417-23.

Jones S.E., Whitehead K., Saulnier D., Thomas C.M., Versalovic J., Britton R.A. Cyclopropane fatty acid synthase mutants of probiotic human-derived Lactobacillus reuteri are defective in TNF inhibition. (2011). Gut Microbes. 2:69-79.

Eaton K.A., Honkala A., Auchtung T.A., Britton R.A. Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree mice. (2011). Infect Immun. 79:185-91.

Schaefer L., Auchtung T.A., Hermans K.E., Whitehead D., Borhan B., Britton R.A. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. (2010). Microbiology. 156:1589-99.

Hüfner E., Britton R.A., Roos S., Jonsson H., Hertel C. Global transcriptional response of Lactobacillus reuteri to the sourdough environment. (2008). Syst Appl Microbiol. 5:323-38.

Cadieux P., Wind A., Sommer P., Schaefer L., Crowley K., Britton R.A., Reid G. Evaluation of Reuterin Production in Urogenital Probiotic Lactobacillus reuteri RC-14. (2008). Appl Environ Microbiol. 15:4645-9.

Whitehead K., Versalovic J., Roos S., Britton R.A. (2008). Genomic and genetic characterization of the bile stress response of probiotic Lactobacillus reuteri ATCC 55730. Appl Environ Microbiol. 74:1812-9.

Wicker-Planquart C., Foucher A.E., Louwagie M., Britton R.A., Jault J.M. (2007). Interactions of an essential Bacillus subtilis GTPase, YsxC, with ribosomes. J Bacteriol. 190:681-90.

Wall T., Båth K., Britton R.A., Jonsson H., Versalovic J., Roos S. (2007). The early response to acid shock in Lactobacillus reuteri involves the ClpL chaperone and a putative cell wall-altering esterase. Appl Environ Microbiol.  73:3924-35.

Britton R.A., Küster-Schöck E., Auchtung T.A., Grossman A.D. (2007). SOS induction in a subpopulation of structural maintenance of chromosome (Smc) mutant cells in Bacillus subtilis.
J Bacteriol. 189:4359-66.

Uicker W.C., Schaefer L., Koenigsknecht M., Britton R.A. (2007). The essential GTPase YqeH is required for proper ribosome assembly in Bacillus subtilis. Journal of Bacteriology. 189(7):2926-9.

Britton R.A., Wen T., Schaefer L., Pellegrini O., Uicker W.C., Mathy N., Tobin C., Daou R., Szyk J., Condon C. (2007). Maturation of the 5' end of Bacillus subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1. Molecular Microbiology. 63:127-38.

Schaefer L., Uicker W.C., Wicker-Planquart C., Foucher A.E., Jault J.M., Britton R.A. (2006). Multiple GTPases participate in the assembly of the large ribosomal subunit in Bacillus subtilis. Journal of Bacteriology. 59:528-40.

Uicker W.C., Schaefer L., Britton R.A. (2006). The essential GTPase RbgA (YlqF) is required for 50S ribosome assembly in Bacillus subtilis. Molecular Microbiology. 59:528-40.


Britton R.A., Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. (2012) Trends Microbiol. 20:313-9.

Walter, J., Britton, R.A. and Roos, S. (2011). Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm. Proc Natl Acad Sci USA. Epub 2010 Jun 25.

Young, V.B., Britton, R.A. and Schmidt, T.M. (2009). The human microbiome and infectious diseases: beyond koch. Interdiscip Perspect Infect Dis. Epub 2009 Mar 29.

Britton, R.A. and Versalovic, J. (2009). Probiotics and gastrointestinal infections. Interdiscip Perspect Infect Dis. Epub 2009 Feb 4.

Britton, R.A. (2009). Role of GTPases in bacterial ribosome assembly. Annu Rev Microbiol. 63:155-76.

Book chapters

Britton, R.A. (2003). DNA microarrays and bacterial gene expression. Methods in Enzymology, RNA polymerase and associated factors. 370:264-78.

Britton, R. A. and Lupski, J. R. (1998). Segregation of the Bacterial Chromosome. In Bacterial Genomes: Physical Structure and Analysis. James R. Lupski, Frans J. deBruijn, George M. Weinstock (eds.), Chapman and Hall, New York, New York. 103-111.

Department of Microbiology & Molecular Genetics Michigan State University
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